TAK-779
Product Specifications
CAS Number
229005-80-5
Synonyms
Takeda 779
Target
CCR
Applications
GPCR & G Protein
Smiles
CC1=CC=C (C=C1) C2=CC3=C (CCCC (=C3) C (=O) NC4=CC=C (C=C4) C[N+] (C) (C) C5CCOCC5) C=C2.[Cl-]
Molecular Formula
C33H39N2O2.Cl
Additionnal Information
TAK-779 (Takeda 779), a nonpeptide compound, is a potent antagonist of CCR5 and CXCR3, with a Ki of 1.1 nM for CCR5. It also exhibits highly potent and selective inhibition of R5 HIV-1 replication with EC50 and EC90 of 1.2 and 5.7 nM, respectively. It also suppresses the development of the cytokine storm in the murine model of the SARS-CoV-2-related acute respiratory distress syndrome.
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