What is the catalog number for MS4078?

The catalog number for MS4078 is S0072-10mM/1mL.

What sizes are available for MS4078?

MS4078 is available in the following size(s): 10 mM/1mL.

MS4078 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures MS4078?

MS4078 is manufactured by Bimake.

What is the estimated delivery time for MS4078?

Estimated delivery time for MS4078 is approximately 15 business day(s), depending on your location.

MS4078

Product Specifications

CAS Number

2229036-62-6

Target

ALK

Applications

Protein Tyrosine Kinase

Smiles

CC1=CC (=C (C=C1C2CCN (CC2) CC (=O) NCCNC3=CC=CC4=C3C (=O) N (C4=O) C5CCC (=O) NC5=O) OC (C) C) NC6=NC=C (C (=N6) NC7=CC=CC=C7S (=O) (=O) C (C) C) Cl

Molecular Formula

C45H52ClN9O8S

Additionnal Information

MS4078 is an inhibitor and PROTAC (degrader) of ALK. MS4078 reduces the NPM-ALK protein levels in SU-DHL-1 cells and the EML4-ALK protein levels in NCI-H2228 cells with DC50 of 11 nM and 59 nM, respectively. MS4078 induces ALK protein degradation via cereblon and proteasome dependent mechanism and potently inhibits proliferation of SU-DHL-1 cells with IC50 of 33 nM.