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Genistein-d4

Genistein-d4 is the deuterium labeled Genistein. Genistein, a soy isoflavone, is a multiple tyrosine kinases (e.g., EGFR) inhibitor which acts as a chemotherapeutic agent against different types of cancer, mainly by altering apoptosis, the cell cycle, and angiogenesis and inhibiting metastasis[1][2].

Product Specifications

Product Name Alternative

NPI 031L-d4

UNSPSC

12352005

Hazard Statement

H302

Target

Apoptosis; Autophagy; EGFR; Endogenous Metabolite

Type

Isotope-Labeled Compounds

Related Pathways

Apoptosis; Autophagy; JAK/STAT Signaling; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Purity

98.81

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1C(C2=C(C([2H])=C(C([2H])=C2[2H])O)[2H])=COC3=CC(O)=CC(O)=C31

Molecular Formula

C15H6D4O5

Molecular Weight

274.26

Precautions

H302

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Peterson G, et al. Genistein inhibits both estrogen and growth factor-stimulated proliferation of human breast cancer cells. Cell Growth Differ. 1996 Oct;7 (10) :1345-51.|[3]Ding S, et al. Environmentally Relevant Dose of Bisphenol A Does Not Affect Lipid Metabolism and Has No Synergetic or Antagonistic Effects on Genistein's Beneficial Roles on Lipid Metabolism. PLoS One. 2016 May 12;11 (5) :e0155352.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-14596S/Genistein-d4-SDS-MedChemExpress.pdf

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

CAS Number

[187960-08-3]

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