GEM144
Product Specifications
CAS Number
2487526-28-1
Synonyms
Flezurafenibum
Target
HDAC
Applications
DNA Damage/DNA Repair
Additionnal Information
GEM144 is a potent and orally active dual inhibitor of DNA polymerase α (POLA1) and HDAC11 . It exhibits potent antiproliferative activity in vitro and antitumor efficacy in vivo by inducing p53 acetylation, p21 activation, G1/S cell cycle arrest, and apoptosis.
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