ABD0171
Product Specifications
Synonyms
Flezurafenibum
Target
Dehydrogenase
Applications
Metabolism
Additionnal Information
ABD0171 is a potent, irreversible, and selective inhibitor of aldehyde dehydrogenase 1A3 (ALDH1A3), with an IC50 of 0.34 μM using the physiological substrate all-trans-retinaldehyde (atRAL) . It also inhibits ALDH1A2 and ALDH1A1 with IC50 of 0.79 μM and 6.6 μM, respectively. ABD0171 disrupts key oncogenic pathways in triple-negative breast cancer (TNBC) cells in vitro and exhibits robust antitumor and antimetastatic activity in vivo.
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