Filipin complex

Filipin complex is a potent polyene macrolide antifungal antibiotic that integrates into membranes, sequestering cholesterol into complexes. Its treatment reduces PRRSV genome copies by 61% and lowers the PRRSV titer. It also acts as a fluorescent histochemical stain prone to autooxidation, commonly used in diagnosing Niemann-Pick Disease Type C (NP-C), a neurodegenerative lysosomal storage disorder. Researchers also employ it to study unesterified cholesterol distribution in cell and animal models of neurodegenerative diseases like NP-C and Sanfilippo syndrome (MPS IIIA) .