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PYZD-4409

Product Specifications

CAS Number

423148-78-1

Target

E1 Activating

Applications

Ubiquitin

Molecular Formula

C14H7ClFN3O5

Additionnal Information

PYZD-4409 is a potent and specific small molecule inhibitor of the ubiquitin-activating enzyme UBA1 (E1) with an IC50 of 20 μM. It induces cell death in malignant cells and preferentially inhibits the clonogenic growth of primary acute myeloid leukemia cells and can be used as a research for developing treatments for hematologic malignancies.

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