Doxepin

Doxepin (MF 10) is a potent inhibitor of serotonin reuptake and noradrenaline reuptake with a Ki of 68 nM and 29.5 nM, respectively. It acts as a receptor antagonist for histamine H1, acetylcholine muscarinic, and α1 adrenoceptor with a Ki of 0.24 nM, 83 nM, and 24 nM, respectively and significantly inhibits CYP450.