CARM1-IN-1

CARM1-IN-1 is a potent and specific CARM1 (Coactivator-associated arginine methyltransferase 1) inhibitor with IC50 of 8.6 uM; shows very low activity against PRMT1 and SET7 (IC50 > 600 uM) . IC50 value: 8.6 uM Target: CRAM1 inhibitorin vitro: CARM1-IN-1 (Cmp 7g) displayed high and selective CARM1 inhibition, with lower or no activity against a panel of different PRMTs or HKMTs. In human LNCaP cells, 7g showed a significant dose-dependent reduction of the PSA promoter activity.