What is the catalog number for L67?

The catalog number for L67 is E7688-5mg.

What sizes are available for L67?

L67 is available in the following size(s): 5 mg.

L67 is currently made to order / not held in immediate stock. Contact us for lead time.

What is the estimated delivery time for L67?

Estimated delivery time for L67 is approximately 15 business day(s), depending on your location.

L67

Product Specifications

CAS Number

325970-71-6

Synonyms

DNA Ligase Inhibitor

Target

DNA/RNA Synthesis

Applications

Cell Cycle

Molecular Formula

C16H14Br2N4O4

Additionnal Information

L67 (DNA Ligase Inhibitor) is a competitive inhibitor of DNA ligase that effectively targets both DNA ligases I and III, with an IC50 of 10 μM for both enzymes. It specifically disrupts mitochondrial DNA metabolism in cancer cells. Inhibition of DNA ligase IIIα (LigIIIα) by L67 leads to significant alterations in mitochondrial morphology, reduces mitochondrial DNA levels, and increases reactive oxygen species (ROS) .