L67
Product Specifications
CAS Number
325970-71-6
Synonyms
DNA Ligase Inhibitor
Target
DNA/RNA Synthesis
Applications
Cell Cycle
Molecular Formula
C16H14Br2N4O4
Additionnal Information
L67 (DNA Ligase Inhibitor) is a competitive inhibitor of DNA ligase that effectively targets both DNA ligases I and III, with an IC50 of 10 μM for both enzymes. It specifically disrupts mitochondrial DNA metabolism in cancer cells. Inhibition of DNA ligase IIIα (LigIIIα) by L67 leads to significant alterations in mitochondrial morphology, reduces mitochondrial DNA levels, and increases reactive oxygen species (ROS) .
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