Almorexant
Product Specifications
CAS Number
871224-64-5
Synonyms
ACT 078573
Additionnal Information
Almorexant (ACT 078573) is an orally active, potent and competitive dual orexin receptor antagonist, with Kd values of 1.3 nM (OX1) and 0.17 nM (OX2), respectively. Almorexant reversibly blocks signaling of orexin-A and orexin-B peptides. Almorexant totally blocked the intracellular Ca2+ signal pathway. Almorexant stimulates caspase-3 activity in AsPC-1 cells and induces apoptosis.
Storage Conditions
3 years-20°C powder 2 years-80°C in solvent
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