C16-Ceramide
Product Specifications
CAS Number
24696-26-2
Synonyms
N-Palmitoylsphingosine
Target
P53
Applications
Apoptosis
Molecular Formula
C34H67NO3
Additionnal Information
C16-Ceramide (N-Palmitoylsphingosine) is a sphingolipid ligand and an activator of p53 tumor suppressor. It tightly binds within the p53 DNA-binding domain with a Kd of ~ 60 nM, in close vicinity to the Box V motif. It regulates the protein ubiquitination and proteasomal degradation and also induces apoptosis in cancer cells making it a research tool for targeting human cancers.
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