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Ponatinib hydrochloride

Product Specifications

CAS Number

1114544-31-8

Synonyms

AP24534 hydrochloride

Target

Bcr-Abl

Applications

Protein Tyrosine Kinase

Molecular Formula

C29H27F3N6O.ClH

Additionnal Information

Ponatinib hydrochloride is a potent, orally available multi-targeted inhibitor of Pan BCR-ABL kinase. It potently inhibits ABL with an IC50 of 0.37 nM, also inhibits SRC , VEGFR2, FGFR1, PDGFRα, LYN with an IC50s of 5.4 nM, 1.5 nM, 2.2 nM, 1.1 nM, 0.24 nM respectively and exhibits significant potential in cancer reserach.

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