What is the catalog number for AMG 410?

The catalog number for AMG 410 is E6406-1mg.

What sizes are available for AMG 410?

AMG 410 is available in the following size(s): 1 mg.

AMG 410 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures AMG 410?

AMG 410 is manufactured by Bimake.

What is the estimated delivery time for AMG 410?

Estimated delivery time for AMG 410 is approximately 15 business day(s), depending on your location.

AMG 410

Product Specifications

CAS Number

3040175-17-2

Target

Ras

Applications

Apoptosis

Molecular Formula

C31H32ClF2N7O5

Additionnal Information

AMG410 is a non-covalent, selective inhibitor of pan-KRAS with IC50 of 1–4 nM for KRAS G12D, G12V, and G13D. It binds both GDP- and GTP-bound KRAS with Kd of 1 nM and 22 nM, respectively. AMG410 inhibits KRAS signaling in a nucleotide cycling-independent manner. It also suppresses proliferation in KRAS-amplified wild-type tumor cells.