Angiotensin I/II (5-8)

Angiotensin II (5-8) is the smallest angiotensin peptide with a potent and selective antinociceptive effect, acting via neuronal-nitric oxide (NO) synthase-soluble guanylyl cyclase (sGC) -endogenous opioid pathway in the ventrolateral periaqueductal gray matter (vlPAG) . It may hold potential for research in metabolic disorders, obesity, and Alzheimer’s disease.