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Tetrabenazine

Product Specifications

CAS Number

718635-93-9

Synonyms

Ro 1-9569

Target

VMAT

Applications

Transmembrane Transporters

Molecular Formula

C19H27NO3

Additionnal Information

Tetrabenazine (Ro 1-9569) is a non-competitive inhibitor of the vesicular monoamine transporter (VMAT), with a higher selectivity for VMAT2 over VMAT1. It exhibits an IC50 of 0.3 μM for VMAT2 and 3 μM for VMAT1, and a Kd of 60 nM for VMAT2 and 9.38 nM for VMAT1. It treats Huntington’s chorea by reducing excessive dopaminergic activity and impairing monoamine storage in synaptic vesicles.

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