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Pexidartinib Hydrochloride

Product Specifications

CAS Number

2040295-03-0

Synonyms

PLX-3397 hydrochloride

Target

CSF-1R

Applications

Protein Tyrosine Kinase

Molecular Formula

C20H15ClF3N5.ClH

Additionnal Information

Pexidartinib Hydrochloride is an oral tyrosine kinase inhibitor of colony-stimulating factor 1 receptor (CSF1R) . It significantly reduces macrophage levels in adipose tissue without altering overall myeloid cell counts in mice. It also induces developmental and immunotoxic effects in zebrafish embryos by hyperactivating Wnt signaling.

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