Pexidartinib Hydrochloride
Product Specifications
CAS Number
2040295-03-0
Synonyms
PLX-3397 hydrochloride
Target
CSF-1R
Applications
Protein Tyrosine Kinase
Molecular Formula
C20H15ClF3N5.ClH
Additionnal Information
Pexidartinib Hydrochloride is an oral tyrosine kinase inhibitor of colony-stimulating factor 1 receptor (CSF1R) . It significantly reduces macrophage levels in adipose tissue without altering overall myeloid cell counts in mice. It also induces developmental and immunotoxic effects in zebrafish embryos by hyperactivating Wnt signaling.
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