LYG-409
Product Specifications
CAS Number
3053857-55-6
Target
E3 Ligase
Applications
Ubiquitin
Molecular Formula
C25H20F3N3O6
Additionnal Information
LYG-409 is a potent, selective, and orally bioavailable degrader of GSPT1, with a DC50 of 7.87 nM. It exhibits strong antiproliferative activity in KG-1 cells with an IC50 of 9.50 nM and demonstrates significant antitumor efficacy in vivo in models of acute myeloid leukemia and prostate cancer.
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