Cabozantinib hydrochloride
Product Specifications
CAS Number
1817759-42-4
Synonyms
XL184, BMS-907351 hydrochloride
Target
C-Met
Applications
Protein Tyrosine Kinase
Molecular Formula
C28H24FN3O5.ClH
Additionnal Information
Cabozantinib hydrochloride (XL184, BMS-907351 hydrochloride) is a potent small-molecule kinase inhibitor of c-MET and VEGFR2 with an IC50 of 1.3 nM, 0.035 nM respectively. It also inhibits RET, KIT, AXL, Tie2 and FLT3 with an IC50's of 5.2 nM, 4.6 nM, 7 nM, 14.3 nM, 11.3nM respectively. It can be promising agent for inhibiting tumor angiogenesis and metastasis in cancers with dysregulated MET and VEGFR signaling.
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS6387661-01 0.1 mL
NT5C (5'(3')-deoxyribonucleotidase, Cytosolic Type, Cytosolic 5',3'-pyrimidine Nucleotidase, Deoxy-5'-nucleotidase 1, dNT-1, DNT1, UMPH2, DNT, DNT-1, P5N2, PN-I, PN-II) (MaxLight 405)
Sign In for Pricing
View Details MBS6387661-02 5x 0.1 mL
NT5C (5'(3')-deoxyribonucleotidase, Cytosolic Type, Cytosolic 5',3'-pyrimidine Nucleotidase, Deoxy-5'-nucleotidase 1, dNT-1, DNT1, UMPH2, DNT, DNT-1, P5N2, PN-I, PN-II) (MaxLight 405)
Sign In for Pricing
View Details 
035530-AP 200 µL
FBLL1, ID (FBLL1, rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1) (AP) discontinued
Sign In for Pricing
View Details 323127 1 Pack (1 Piece (s) x 1 Piece)
MC300E+-ULTRA-5Y Training Services
Sign In for Pricing
View Details 
MBS6384048-01 0.1 mL
LAP3 (Cytosol Aminopeptidase, Leucine Aminopeptidase 3, LAP-3, Leucyl Aminopeptidase, Peptidase S, Proline Aminopeptidase, Prolyl Aminopeptidase, LAPEP, PEPS) (AP)
Sign In for Pricing
View Details