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Lodoxamide

Product Specifications

CAS Number

53882-12-5

Synonyms

U-42585E free acid

Target

GPR

Applications

GPCR & G Protein

Molecular Formula

C11H6ClN3O6

Additionnal Information

Lodoxamide (U-42585E free acid) is a potent agonist of GPR35 with an EC50 of 1 nM. It also inhibits eosinophil peroxidase release after IgA activation and reduces eosinophil cationic protein and eosinophil-derived neurotoxin, suggesting direct effects on eosinophils. It is a mast cell stabilizer used to treat asthma, allergic conjunctivitis, and superior limbic keratoconjunctivitis.

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