Niraparib hydrochloride
Product Specifications
CAS Number
1038915-64-8
Synonyms
MK-4827 hydrochloride
Target
PARP
Applications
DNA Damage/DNA Repair
Molecular Formula
C19H20N4O.ClH
Additionnal Information
Niraparib hydrochloride (MK-4827 hydrochloride) is a potent poly (ADP-ribose) polymerase (PARP) inhibitor with IC50s of 3.8 and 2.1 nM against both the PARP-1 and PARP-2 enzymes, respectively.It inhibits the repair of radiation-induced DNA double-strand breaks, activates apoptosis, and exhibits anti-tumor activity.
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