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Afatinib free base

Product Specifications

CAS Number

439081-18-2

Synonyms

Gilotrif, BIBW2992, Boehringer Ingelheim

Target

EGFR

Applications

Protein Tyrosine Kinase

Molecular Formula

C24H25ClFN5O3

Additionnal Information

Afatinib free base (Gilotrif, BIBW2992, Boehringer Ingelheim) is a second-generation tyrosine kinase inhibitor (TKI) that irreversibly inhibits EGFR and HER2, with IC50 of 0.5 nM, 0.4 nM, 14 nM and 1 nM for wild-type EGFR, EGFR-L858R, HER2, ErbB4, respectively.

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