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STL127705

Product Specifications

CAS Number

1326852-06-5

Molecular Formula

C22H20FN5O4

Additionnal Information

STL127705 is a potent small molecule inhibitor of Ku70/80 heterodimer protein with an IC50 of 3.5 μM. It disrupts Non-Homologous End-Joining (NHEJ) by preventing DNA binding and inhibiting DNA-PKCS activation. It exhibits anticancer activity by inducing apoptosis and inhibiting cell proliferation.

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