BMS-986397
Product Specifications
CAS Number
2564486-44-6
Synonyms
CC-91633
Target
Casein Kinase
Applications
Cell Cycle
Molecular Formula
C21H16ClF3N4O4
Additionnal Information
BMS-986397 (CC-91633) is a potent and selective thalidomide-derived molecular glue degrader of CK1α and a modulator of CRBN E3 ubiquitin ligase. As a first-in-class CELMoD agent, it exhibits strong anti-leukemic activity in AML (Acute Myeloid Leukemia) and HR-MDS (High-Risk Myelodysplastic Syndrome) models, with enhanced efficacy and potency for hematologic malignancies and immunomodulation.
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