MIRA-1

MIRA-1 (NSC 19630), a maleimide compound, is a selective inhibitor of Werner syndrome WRN helicase activity with an IC50 of 20 μM while sparing ATPase and exonuclease activities. It reactivates mutant p53, inducing apoptosis in various human solid tumor cell lines with tetracycline-regulated mutant p53.