BHPI
Product Specifications
CAS Number
56632-39-4
Target
Estrogen/progestogen Receptor
Applications
Endocrinology & Hormones
Molecular Formula
C21H17NO3
Additionnal Information
BHPI is a potent noncompetitive inhibitor of estrogen receptor α (ERα), which disrupts the protective estrogen–ERα-mediated activation of the unfolded protein response (UPR), leading to sustained UPR activation. It specifically inhibits the growth of drug-resistant ERα-positive breast and ovarian cancer cells and induces significant tumor regression in a mouse xenograft model of breast cancer.
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