Buloxibutid
Product Specifications
CAS Number
477775-14-7
Synonyms
AT2 Agonist C21
Target
Angiotensin Receptor
Applications
GPCR & G Protein
Molecular Formula
C23H29N3O4S2
Additionnal Information
Buloxibutid (AT2 Agonist C21) is a selective agonist of angiotensin II type 2 receptor (AT2R) with a Ki value of 0.4 nM for the AT2 receptor and a Ki >10 μM for the AT1 receptor. Its treatment significantly reduces vascular remodelling, improves hemodynamics, and decreases pulmonary collagen deposition in the Sugen-Hypoxia model of pulmonary hypertension.
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