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Buloxibutid

Product Specifications

CAS Number

477775-14-7

Synonyms

AT2 Agonist C21

Target

Angiotensin Receptor

Applications

GPCR & G Protein

Molecular Formula

C23H29N3O4S2

Additionnal Information

Buloxibutid (AT2 Agonist C21) is a selective agonist of angiotensin II type 2 receptor (AT2R) with a Ki value of 0.4 nM for the AT2 receptor and a Ki >10 μM for the AT1 receptor. Its treatment significantly reduces vascular remodelling, improves hemodynamics, and decreases pulmonary collagen deposition in the Sugen-Hypoxia model of pulmonary hypertension.
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