CSRM617 hydrochloride
Product Specifications
CAS Number
1353749-74-2
Target
Others
Applications
Others
Molecular Formula
C10H13N3O5.ClH
Additionnal Information
CSRM617 hydrochloride is a selective small-molecule inhibitor of the transcription factor ONECUT2 (OC2, a master regulator of androgen receptor) with a Kd of 7.43 uM in SPR assays, binding to OC2-HOX domain directly. It induces apoptosis by appearance of cleaved Caspase-3 and PARP and is well tolerated in the prostate cancer mouse model.
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