JNJ-10198409
Product Specifications
CAS Number
627518-40-5
Target
PDGFR
Applications
Protein Tyrosine Kinase
Smiles
COC1=CC2=C (C=C1OC) C3=C (C2) C (=N[NH]3) NC4=CC=CC (=C4) F
Molecular Formula
C18H16FN3O2
Additionnal Information
JNJ-10198409, a relatively selective, orally active, and ATP competitive PDGF-RTK (platelet-derived growth factor receptor tyrosine kinase) inhibitor with IC50 of 2 nM, is a dual-mechanism, antiangiogenic, and tumor cell antiproliferative agent, has good activity against PDGFRβ kinase and PDGFRα kinase with IC50 of 4.2 and 45 nM, respectively.
Storage Conditions
3 years -20°C powder
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