R16
Product Specifications
CAS Number
6325-13-9
Synonyms
NSC29869, Nrf2-IN-3
Target
Nrf2
Applications
NF-κB
Molecular Formula
C22H26N4O4S
Additionnal Information
R16 (NSC29869, Nrf2-IN-3) is an inhibitor of NRF2 (nuclear factor erythroid 2-related factor 2) that selectively binds KEAP1 mutants and restores their NRF2-inhibitory function by repairing the disrupted KEAP1/NRF2 interactions. It significantly enhances the sensitivity of KEAP1-mutated tumor cells to cisplatin and gefitinib.
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