VVD-214
Product Specifications
CAS Number
3026500-20-6
Synonyms
RO7589831, VVD-133214
Target
Others
Applications
Others
Molecular Formula
C20H21F2N3O4S
Additionnal Information
VVD-214 (RO7589831, VVD-133214) is a synthetic allosteric inhibitor of WRN helicase. VVD-214 binds irreversibly to cysteine 727 on WRN, suppressing ATP hydrolysis and helicase activity. VVD-214 exhibits potent efficacy in inducing double-stranded DNA breaks, nuclear enlargement, and cellular apoptosis in cancers with high microsatellite instability (MSI) .
More Discoveries
Explore Other Products
Browse additional items from our catalog
abx310766-01 20 µg
Mediator Complex Subunit 28 (MED28) Antibody (HRP)
Sign In for Pricing
View Details abx310766-02 50 µg
Mediator Complex Subunit 28 (MED28) Antibody (HRP)
Sign In for Pricing
View Details abx310766-03 100 µg
Mediator Complex Subunit 28 (MED28) Antibody (HRP)
Sign In for Pricing
View Details abx310766-04 200 µg
Mediator Complex Subunit 28 (MED28) Antibody (HRP)
Sign In for Pricing
View Details 
abx310766-05 1 mg
Mediator Complex Subunit 28 (MED28) Antibody (HRP)
Sign In for Pricing
View Details