Pevonedistat hydrochloride
Product Specifications
CAS Number
1160295-21-5
Synonyms
MLN4924 hydrochloride
Target
E1 Activating
Applications
Ubiquitin
Molecular Formula
C21H25N5O4S.ClH
Additionnal Information
Pevonedistat hydrochloride (MLN4924 hydrochloride) is a potent and selective inhibitor of NEDD8-activating enzyme (NAE) with an IC50 of 4.7 nM. It disrupts cullin-RING ligase-mediated protein degradation, leading to apoptotic cell death in human tumor cells through the deregulation of S-phase DNA synthesis.
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