ART899
Product Specifications
CAS Number
2607139-85-3
Target
DNA/RNA Synthesis
Applications
Cell Cycle
Molecular Formula
C19H13ClD3F4N3O4
Additionnal Information
ART899, a derivative of ART558 is a potent, specific allosteric inhibitor of DNA polymerase theta (Polθ), specifically inhibits Polθ MMEJ activity with IC50 of 180 nM. It specifically radiosensitizes tumor cells and have a potent stand-alone antitumor effect in cancer cells.
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