HRX215
Product Specifications
CAS Number
2369583-33-3
Synonyms
Darizmetinib
Target
P38 MAPK
Applications
MAPK
Molecular Formula
C21H17F2N5O3S
Additionnal Information
HRX215 (Darizmetinib) is a first-in-class, highly potent, selective, and orally active inhibitor of MKK4 with an IC50 of 0.02 μM. It enhances liver regeneration, prevents liver failure following extensive hepatectomy in pigs, and has potential to prevent liver failure after major oncological liver resections or transplantation of small liver grafts in humans.
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