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Lorundrostat

Product Specifications

CAS Number

1820940-17-7

Synonyms

MT-4129

Target

P450 (e.g. CYP17)

Applications

Metabolism

Molecular Formula

C24H33N7O2

Additionnal Information

Lorundrostat (MT-4129) is a highly selective inhibitor of CYP11B2 (aldosterone synthase), with inhibition constant (Ki) values of 1.27 nM for hCYP11B2 and 475 nM for hCYP11B1. It demonstrates potential as a safe and effective treatment for aldosterone-dependent uncontrolled hypertension, including cases of treatment-resistant hypertension.

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