KT 474
Product Specifications
CAS Number
2432994-31-3
Synonyms
SAR-444656
Target
IRAK
Applications
Immunology & Inflammation
Molecular Formula
C44H49F2N11O6
Additionnal Information
KT-474 (SAR444656) is a selective small-molecule degrader of IRAK4 in development for the treatment of TLR/IL-1R–driven autoimmune diseases. KT-474 potently downregulates R848 (TLR7/8) and lipopolysaccharide (LPS) -induced IL-6 and IL-8 production in peripheral blood mononuclear cells (PBMCs) .
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