Exarafenib
Product Specifications
CAS Number
2639957-39-2
Synonyms
KIN-002787, KIN-2787, RAF/KIN_2787
Target
Raf
Applications
MAPK
Molecular Formula
C26H34F3N5O3
Additionnal Information
Exarafenib (KIN-002787, KIN-2787, RAF/KIN_2787) is an orally-available, selective inhibitor of pan-RAF. Exarafenib is effective in RAF-dependent cancers, including all classes of BRAF alterations. Exarafenib suppresses MAPK signaling in RAF-dependent melanoma cell lines. KIN-2787 exhibits low nanomolar to picomolar potency against RAF1, BRAF, and ARAF with an IC50 of 0.06-3.46 nM with minimal activity towards non-RAF kinases.
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