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Elsubrutinib

Product Specifications

CAS Number

1643570-24-4

Synonyms

ABBV-105

Target

BTK

Applications

Protein Tyrosine Kinase

Molecular Formula

C17H19N3O2

Additionnal Information

Elsubrutinib (ABBV-105) is a covalent, irreversible, potent, and highly selective inhibitor of Bruton’s Tyrosine Kinase (BTK), with an IC50 of 0.18 μM for BTK catalytic domain. It specifically inhibits BTK dependent cellular functions, including both BCR and FcγR mediated signaling. It also exhibits significant efficacy in pre-clinical mechanistic models of antibody production, as well as in models of rheumatoid arthritis and lupus.

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