LUNA18
Product Specifications
CAS Number
2676177-63-0
Synonyms
Paluratide
Target
Ras
Applications
Apoptosis
Molecular Formula
C73H105F5N12O12
Additionnal Information
LUNA18 (Paluratide) is an orally bioavailable 11-mer cyclic peptide KRAS inhibitor for the intracellular tough target RAS. It binds to KRASG12D with a kd of 0.043 nM and blocks KRASG12D–SOS1 interaction at IC50 of < 2.2 nM. It also exhibits antiproliferative activity in KRAS-mutant cancer cell lines with an IC50 of 1.4 nM in AsPC-1 pancreatic cancer cells.
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
K1043504 1.0 µg DNA
IGHV4-55 sgRNA CRISPR Lentivector (Human) (Target 3)
Sign In for Pricing
View Details RC224952L3 10 µg
CDC2L5 (CDK13) (NM_031267) Human Tagged Lenti ORF Clone
Sign In for Pricing
View Details 
MBS6138263-01 0.1 mL
PIK3R4 (Phosphoinositide 3-kinase Regulatory Subunit 4, PI3-kinase Regulatory Subunit 4, PI3-kinase p150 Subunit, Phosphoinositide 3-kinase Adaptor Protein, MGC102700, p150, VPS15) APC
Sign In for Pricing
View Details MBS6138263-02 5x 0.1 mL
PIK3R4 (Phosphoinositide 3-kinase Regulatory Subunit 4, PI3-kinase Regulatory Subunit 4, PI3-kinase p150 Subunit, Phosphoinositide 3-kinase Adaptor Protein, MGC102700, p150, VPS15) APC
Sign In for Pricing
View Details