Brigimadlin
Product Specifications
CAS Number
2095116-40-6
Synonyms
BI 907828
Target
MDM2/MDMX
Applications
Apoptosis
Molecular Formula
C31H25Cl2FN4O3
Additionnal Information
Brigimadlin (BI 907828) is a potent, orally active inhibitor of E3 ubiquitin-protein ligase MDM-2. Brigimadlin inhibits MDM-2's suppression of the tumor suppressor p53. It promotes apoptosis and enhances the transcription of p53 targets such as p21 and PUMA in BT48, BT67, and BT73 cells.
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