I-138
Product Specifications
CAS Number
2098211-50-6
Target
DUB
Applications
Ubiquitin
Molecular Formula
C26H23F3N6O
Additionnal Information
I-138 is an orally active, potent reversible inhibitor of USP1-UAF1 with IC50 0f 4.1 nM. I-138 is structurally related to ML323 and induces the monoubiquitination of FANCD2 and PCNA in MDA-MB-436 cells and increases PCNA and FANCD2 monoubiquitination in HAP-1 USP1 WT cells.
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