Bexotegrast
Product Specifications
CAS Number
2376257-44-0
Synonyms
PLN-74809
Target
Integrin
Applications
Cytoskeletal Signaling
Molecular Formula
C27H36N6O3
Additionnal Information
Bexotegrast (PLN-74809) is potent dual selective inhibitor of αvβ6 and αvβ1 integrins with Kd of 5.7 nM and 3.4 nM, respectively. It has antifibrogenic effects, blocks multiple TGF-β activation pathways in the fibrotic lung, and is useful for researching fibrosis, including idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP) .
Storage Conditions
2 years -20°C liquid
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