MDL-800
Product Specifications
CAS Number
2275619-53-7
Target
Sirtuin
Applications
DNA Damage/DNA Repair
Molecular Formula
C21H16BrCl2FN2O6S2
Additionnal Information
MDL 800 is an allosteric activator of sirtuin 6 (SIRT6) . It selectively activates SIRT6 deacetylase activity over SIRT1-5 and -7 and histone deacetylase 1 (HDAC1) and HDAC2-11 deacetylase activity in cell-free assays at 100 μM. It induces histone deacetylation, and reduces proliferation of BEL-7405 hepatocellular carcinoma (HCC) cells with EC50 of 90.4 μM.
Storage Conditions
3 years -20°C powder
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