What is the catalog number for UNC6934?

The catalog number for UNC6934 is E1059-5mg.

What sizes are available for UNC6934?

UNC6934 is available in the following size(s): 5 mg.

UNC6934 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures UNC6934?

UNC6934 is manufactured by Bimake.

What is the estimated delivery time for UNC6934?

Estimated delivery time for UNC6934 is approximately 15 business day(s), depending on your location.

UNC6934

Product Specifications

CAS Number

2561494-77-5

Target

NSD

Applications

Epigenetics

Smiles

O=C1COC2=C (N1) C=CC (=C2) C (=O) N (CC3=CC=C (C=C3) C (=O) NC4=CC=NC=N4) C5CC5

Molecular Formula

C24H21N5O4

Additionnal Information

UNC6934 is a a chemical probe targeting the N-terminal PWWP (PWWP1) domain of NSD2. UNC6934 is a potent antagonist of NSD2-PWWP1 with a Kd (SPR) of 80 nM and is selective for NSD2-PWWP1 over 14 other PWWP domains including NSD3-PWWP1 UNC6934 disrupts the NSD2-PWWP1 interaction with H3K36me2 nucleosomes in U2OS cells as measured by a NanoBret assay with an IC50 of 1.09 μM.