GW280264X
Product Specifications
CAS Number
866924-39-2
Molecular Formula
C28H41N5O6S
Additionnal Information
GW280264X is a potent hydroxamate inhibitor of mixed ADAM10/TACE (ADAM17) . It potently blocks TACE (ADAM17) and ADAM10 with IC50s of 8.0 nM and 11.5 nM, respectively. It inhibits constitutive and PMA-inducible CX3CL1 shedding and increases adhesive properties in CX3CL1 transfected cells. Its treatment significantly improves functional recovery after spinal cord injury.
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