N-Desmethyltamoxifen
Product Specifications
CAS Number
31750-48-8
Target
PKC
Applications
Cytoskeletal Signaling
Smiles
CC/C (C1=CC=CC=C1) =C (C2=CC=CC=C2) /C3=CC=C (OCCNC) C=C3
Molecular Formula
C25H27NO
Additionnal Information
N-Desmethyltamoxifen, the major metabolite of Tamoxifen in humans and a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen, also is a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation.
Storage Conditions
3 years -20°C powder
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