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N-Desmethyltamoxifen

Product Specifications

CAS Number

31750-48-8

Target

PKC

Applications

Cytoskeletal Signaling

Smiles

CC/C (C1=CC=CC=C1) =C (C2=CC=CC=C2) /C3=CC=C (OCCNC) C=C3

Molecular Formula

C25H27NO

Additionnal Information

N-Desmethyltamoxifen, the major metabolite of Tamoxifen in humans and a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen, also is a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation.

Storage Conditions

3 years -20°C powder

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